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To supplement hits from a high through put screening, a docking study on butenolides derivatives was performed as COX-II inhibitors. The fourteen ligands were docked inside the ligand-binding domain (LBD) of protein data bank PDB ID: 3HS5 utilizing Maestro version 9. Out of 14 compounds, compounds I and XII were found to embed in the hydrophobic pocket by forming hydrogen bonds with the amino acids...
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