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Background
The effect of calcium channel blockers (CCB) on mortality and ischaemic stroke risk in dementia patients is understudied.
Objectives
To calculate the risk of death and ischaemic stroke in dementia patients treated with CCBs, considering individual agents and dose response.
Methods
Longitudinal cohort study with 18 906 hypertensive dementia patients from the Swedish Dementia Registry...
Millions of people worldwide receive agents targeting the renin–angiotensin system (RAS) to treat hypertension or statins to lower cholesterol. The RAS and cholesterol metabolic pathways in the brain are autonomous from their systemic counterparts and are interrelated through the cholesterol metabolite 27‐hydroxycholesterol (27‐OHC). These systems contribute to memory and dementia pathogenesis through...
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