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The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B, and is theoretically capable of producing four NBCn2 splice variants: NBCn2-A, -B, -C, and -D. By immunoprecipitation and western blotting, a previous study showed the putative NBCn2-D to be expressed predominantly in the subcortex (SCX) and medulla (MD) of mouse brain...
Na-coupled HCO 3 transporters (NCBTs) play important roles in brain pH regulation. One NCBT, the Na-driven Cl-HCO 3 exchanger (SLC4A8 or NDCBE), appears to be the major regulator of intracellular pH (pH i ), at least in some hippocampal pyramidal neurons. NDCBE is widely expressed throughout the central nervous system in rodent brain. In a previous study, it has been demonstrated...
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