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Purpose Excessive free iron induces retinal toxicity in several human diseases and has been linked to age‐related macular degeneration. Iron toxicity is widely attributed to its ability to catalyze hydroxyl radical formation through Fenton’s reaction. Iron was recently described as an inhibitor of canonical DICER1 enzymatic activity through sequestration of the cofactor poly(C)‐binding protein 2 (PCBP2)...
High‐mobility group box 1 (HMGB1) is an endogenous alarm sensor against extracellular damage signals and initiates TLR (toll‐like receptor) responses closely linked to angiogenesis through MyD88, its specific adaptor protein. Interest in regulation of HMGB1‐TLR as a potential therapeutic approach is increasing but this regulatory effect in pathologic angiogenesis still remains unclear. Through a mouse...
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