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Background
Serological immunoassays that can identify protective immunity against SARS‐CoV‐2 are needed to adapt quarantine measures, assess vaccination responses, and evaluate donor plasma. To date, however, the utility of such immunoassays remains unclear. In a mixed‐design evaluation study, we compared the diagnostic accuracy of serological immunoassays that are based on various SARS‐CoV‐2 proteins...
Background
Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims of the study were to assess the incidence of cephalosporin‐induced anaphylaxis and evaluate the clinical efficacy of screening skin tests.
Methods
In this retrospective cohort study, we obtained information on total cephalosporin use and cephalosporin‐induced...
Background
Microbial colonization of the airway plays a role in the pathogenesis of asthma; however, the effect of the upper airway microbiome on childhood asthma is not fully understood. We analyzed the metagenome of airway microbiome to understand the associated role of upper airway microbiome with the natural course of childhood asthma.
Methods
Nasopharyngeal swabs were collected from children...
Background
Asthma is a Th2 cell‐driven inflammatory disease and a major public health concern. The cis‐acting element Rad50 hypersensitive site 6 (RHS6) in the Th2 locus control region is essential for regulation of the Th2 cytokine genes; however, its role in allergic airway inflammation and underlying molecular mechanisms of the regulation by RHS6 are poorly understood.
Objective
We sought to...
BackgroundNational Health Insurance (NHI) claim records could provide valuable data for epidemiological studies of asthma in Korea. The aim of this study is to estimate the prevalence of adult asthma and to investigate asthma‐related healthcare use and prescription patterns in Korea over 5 years.
MethodsNational Health Insurance claim records from January 1, 2006 to December 31, 2010 were analyzed...
BackgroundCephalosporin is a major offending agent in terms of drug hypersensitivity along with penicillin. Cephalosporin intradermal skin tests (IDTs) have been widely used; however, their validity for predicting immediate hypersensitivity has not been studied. This study aimed to determine the predictive value of cephalosporin intradermal skin testing before administration of the drug.
MethodsWe...
BackgroundEnzyme replacement therapy (ERT) with recombinant human idursulfase is effective for the treatment of Hunter syndrome, mucopolysaccharidosis (MPS) type II. However, various adverse events can occur by the infusion of idursulfase. The purpose was to evaluate the occurrence of infusion‐related allergic reactions, including anaphylaxis, to idursulfase in patients with MPS II receiving ERT and...
BackgroundRecent evidence indicates that Staphylococcus aureus, one of the most important human pathogens, secretes vesicles into the extracellular milieu.
ObjectiveTo evaluate whether inhalation of S. aureus‐derived extracellular vesicles (EV) is causally related to the pathogenesis of inflammatory pulmonary diseases.
MethodsStaphylococcus aureus EV were prepared by sequential ultrafiltration and...
BackgroundViral pathogen–associated molecular patterns, such as dsRNA, disrupt airway tolerance to inhaled allergens. Specifically, the Th2 and Th17 cell responses are induced by low‐dose dsRNA and the Th1‐dominant response by high‐dose dsRNA.
ObjectiveIn this model, we evaluate the role of TNF‐α in the development of adaptive immune dysfunction to inhaled allergens induced by airway sensitization...
To cite this article: Hong S‐W, Kim M‐R, Lee E‐Y, Kim JH, Kim Y‐S, Jeon SG, Yang J‐M, Lee B‐J, Pyun B‐Y, Gho YS, Kim Y‐K. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis‐like skin inflammation. Allergy 2011; 66: 351–359.
AbstractBackground: Recently, we found that Staphylococcus aureus produces extracellular vesicles (EV) that contain pathogenic proteins. Although...
To cite this article: Shin T‐S, Kim JH, Kim Y‐S, Jeon SG, Zhu Z, Gho YS, Kim Y‐K. Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy 2010; 65: 1256–1265.
AbstractBackground: Previous evidence indicates that inhalation of lipopolysaccharide (LPS)‐containing with allergens induced mixed Th1 and Th17 cell responses in...
To cite this article: Choi J‐P, Kim Y‐S, Tae Y‐M, Choi E‐J, Hong B‐S, Jeon SG, Gho YS, Zhu Z, Kim Y‐K. A viral PAMP double‐stranded RNA induces allergen‐specific Th17 cell response in the airways which is dependent on VEGF and IL‐6. Allergy 2010; 65: 1322–1330.
AbstractBackground: Innate immune response by a viral pathogen‐associated molecular pattern dsRNA modulates the subsequent development of...
To cite this article: Moon H‐G, Tae Y‐M, Kim Y‐S, Gyu Jeon S, Oh S‐Y, Song Gho Y, Zhu Z, Kim Y‐K. Conversion of Th17‐type into Th2‐type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy 2010; 65: 1093–1103.
AbstractBackground: Allergen‐specific T‐cell responses orchestrate airway inflammation, which is a characteristic of asthma. Recent evidence suggests...
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