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Two high-throughput screening hits were investigated for SAR against human factor IXa. Both hits feature a benzamide linked to a [6-5]-heteroaryl via an alkyl amine. In the case where this system is a benzimidazolyl-ethyl amine the binding potency for the hit was improved >500-fold, from 9μM to 0.016μM. For the other hit, which contains a tetrahydropyrido-indazole amine, potency was improved 20-fold,...
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