Wyniki wyszukiwania dla: Qing-Shan Yan

Pozycje od 1 do 16 spośród 16 wyników

artykuł

RNA interference-mediated inhibition of brain-derived neurotrophic factor expression increases cocaine's cytotoxicity in cultured cells

Qing-Shan Yan, Mei-Jinag Feng, Shu-E Yan

Neuroscience Letters > 2007 > 414 > 2 > 165-169

Previous studies showed that cocaine exposure decreased brain-derived neurotrophic factor (BDNF) function and resulted in neuronal cell death. To investigate a role of BDNF in cocaine's cytotoxicity, an RNA interference (RNAi) approach was used. Transfection of neuroblastoma SK-N-AS cells or primary rat hippocampal neurons with the small double-stranded interfering RNA (siRNA) targeting BDNF mRNA,...

artykuł

Cocaine exposure at a sublethal concentration downregulates CREB functions in cultured neuroblastoma cells

Mei-Jiang Feng, Shu-E Yan, Qing-Shan Yan

Brain Research > 2006 > 1077 > 1 > 59-66

Previous studies showed that prenatal cocaine in an animal model decreased brain-derived neurotrophic factor (BDNF) activity in offspring's brain. Since BDNF is one of target genes of cAMP response element-binding protein (CREB), this study examined effects of cocaine on CREB activities in a human neuroblastoma (SK-N-AS) cell line. The MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazodium bromide)...

artykuł

Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission

Qing-Shan Yan, Shi-Zhong Zheng, Mei-Jiang Feng, Shu-E Yan

Brain Research > 2005 > 1060 > 1-2 > 126-137

Evidence suggests that 5-hydroxytriptamine-1B (5-HT _1B ) receptors play a role in modifying ethanol's reinforcing effects and voluntary intake, and that 5-HT _1B receptors within the ventral tegmental area (VTA) are involved in regulation of mesolimbic dopaminergic neuronal activity. Since increased mesolimbic dopaminergic transmission has been implicated in ethanol's reinforcing properties,...

artykuł

Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring

Mei-Jiang Feng, Shu-E Yan, Qing-Shan Yan

Brain Research > 2005 > 1042 > 2 > 125-132

Prenatal alcohol exposure produces many developmental defects in the central nervous system. The underlying molecular mechanism, however, has not been fully understood. The present study was undertaken to examine the effects of prenatal alcohol exposure on brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) in offspring. The pregnant Sprague–Dawley rats received 1 or...

artykuł

Different expression of brain-derived neurotrophic factor in the nucleus accumbens of alcohol-preferring (P) and -nonpreferring (NP) rats

Qing-Shan Yan, Mei-Jiang Feng, Shu-E Yan

Brain Research > 2005 > 1035 > 2 > 215-218

Recent studies suggest that the gene that encodes brain-derived neurotrophic factor (BDNF) might be linked with vulnerability to alcohol abuse. We have now compared BDNF protein levels in several brain regions between alcohol-naïve alcohol-preferring (P) and -nonpreferring (NP) rats using the enzyme-linked immunosorbent assay (ELISA) procedure. The results showed that BDNF levels in the nucleus accumbens...

artykuł

Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis

Qing-Shan Yan, Shi-Zhong Zheng, Shu-E Yan

Brain Research > 2004 > 1021 > 1 > 82-91

This study was designed to assess the involvement of 5-HT _1B receptors within the ventral tegmental area (VTA) in the regulation of mesolimbic dopaminergic transmission. Dual-probe microdialysis was performed in freely moving adult Sprague–Dawley rats with one probe within the VTA and the other within the ipsilateral nucleus accumbens (NACC). Drugs were administered into the VTA via retrograde...

artykuł

Prenatal cocaine exposure decreases brain-derived neurotrophic factor proteins in the rat brain

Qing-Shan Yan, Shi-Zhong Zheng, Shu-E Yan

Brain Research > 2004 > 1009 > 1-2 > 228-233

The pregnant rats received daily sc injections of cocaine (30 mg/kg) or saline from the gestational day (GD) 7 to GD 20. At 1 week postnatal, all pups were killed and the hippocampus, cortex and striatum were dissected out. Levels of brain-derived neurotrophic factor (BDNF) under the basal condition and depolarization with high potassium (40 mM) were measured. The results showed that hippocampal BDNF...

artykuł

Involvement of non-exocytotic mechanisms in ethanol-induced in vivo dopamine release: comparisons with cocaine

Qing-Shan Yan

European Journal of Pharmacology > 2003 > 477 > 1 > 37-44

In order to determine whether a non-exocytotic mechanism was involved in ethanol-induced in vivo dopamine release in the nucleus accumbens, extracellular dopamine concentrations were measured via intracerebral microdialysis in freely moving Sprague-Dawley rats. Effects of ethanol on dopamine release in the nucleus accumbens were compared with those by cocaine, a drug that increases synaptic dopamine...

artykuł

Ethanol-induced, nonexocytotic [ ³ H]dopamine release from rat nucleus accumbens slices

Qing-Shan Yan

Alcohol > 2002 > 27 > 2 > 127-134

This study was designed to investigate whether a carrier-dependent mechanism is involved in ethanol-induced dopamine release in vitro. Rat nucleus accumbens slices were incubated with [ ³ H]dopamine in the presence of pargyline and then superfused. Spontaneous [ ³ H]dopamine release was unaffected by addition of tetrodotoxin or withdrawal of calcium, but was increased significantly...

artykuł

Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure

Qing-Shan Yan

Brain Research > 2002 > 929 > 1 > 59-69

This study was designed to assess the effects of prenatal cocaine exposure on the development of the serotonergic system. Pregnant Sprague-Dawley rats received daily sc injections of either cocaine (30 mg/kg) or saline from gestation day 7 (GD 7) to GD 20. At 1 week postnatal, all pups were killed and tissues containing the striatum and nucleus accumbens dissected out. In superfusion experiments,...

artykuł

Activation of 5-HT ₁ _B _/ ₁ _D receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study

Qing-Shan Yan, Shu-E Yan

European Journal of Pharmacology > 2001 > 418 > 1-2 > 55-64

This study was designed to investigate the role of 5-hydroxytryptamine (5-HT) ₁ _B receptors located in the ventral tegmental area and nucleus accumbens in the modulation of accumbal dopaminergic transmission. The selective 5-HT ₁ _B receptor agonist CP 93129 {3-(1,2,5,6-tetrahydro-4-pyridyl)pyrrolo[3,2-b]pyrid-5-one} was administered into the ventral tegmental area or nucleus...

artykuł

Enhanced accumbal dopamine release following 5-HT ₂ _A receptor stimulation in rats pretreated with intermittent cocaine

Qing-Shan Yan, Maarten E.A. Reith, Shue Yan

Brain Research > 2000 > 863 > 1-2 > 254-258

This study was conducted to determine whether dopamine (DA) release in the nucleus accumbens (NACC) following 5-HT ₂ _A receptor stimulation is potentiated by intermittent cocaine. Rats received daily injections of either saline or cocaine (30 mg/kg, s.c.) for 14 days. At the 7th day after withdrawal, microdialysis was performed in the NACC. Infusion of (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane...

artykuł

Activation of 5-HT ₂ _A _/ ₂ _C receptors within the nucleus accumbens increases local dopaminergic transmission - Role of calcium-dependent release mechanisms

Qing-Shan Yan

Brain Research Bulletin > 2000 > 51 > 1 > 75-81

This study was designed to assess the involvement of the 5-hydroxytryptamine (5-HT) ₂ _A _/ ₂ _C receptor subtypes in the regulation of in vivo dopamine release in the rat nucleus accumbens (NAC). Extracellular dopamine (DA) in the NAC was measured using intracerebral microdialysis coupled with an HPLC-EC system. 5-HT ₂ _A _/ ₂ _C receptor agonist, (+/-)-1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane...

artykuł

Dizocilpine (MK-801) increases not only dopamine but also serotonin and norepinephrine transmissions in the nucleus accumbens as measured by microdialysis in freely moving rats

Qing-Shan Yan, Maarten E.A Reith, Phillip C Jobe, John W Dailey

Brain Research > 1997 > 765 > 1 > 149-158

The extracellular concentrations of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the nucleus accumbens (NACC) of freely moving rats were monitored simultaneously via intracerebral microdialysis. Local infusion of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 (dizocilpine) (5–250 μM) produced significant increases in extracellular levels of DA, NE and 5-HT...

artykuł

Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers

M. E. A. Reith, Ming-Ya Li, Qing-Shan Yan

Psychopharmacology > 1997 > 134 > 3 > 309-317

Abstract Extracellular levels of dopamine (DA), serotonin (5-HT), and norepinephrine (NE) were measured by microdialysis in conscious rats equipped with dual probes, one in the ventral tegmental area (VTA) and another one in the contralateral nucleus accumbens (NACC). Dialysate content of all amines in both regions was essentially abolished by local infusion of tetrodotoxin (1M) or Ca2+-free buffer...

artykuł

Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats

Qing-Shan Yan, Phillip C. Jobe, Jae Hoon Cheong, Kwang Ho Ko, więcej

Naunyn-Schmiedeberg's Archives of Pharmacology > 1994 > 350 > 2 > 149-152

Abstract. This study was designed to demonstrate a role of serotonin in the anticonvulsant effect of fluoxetine, a serotonin reuptake inhibitor, in genetically epilepsy-prone rats. When varied doses of 5-hydroxytryptophan (12.5, 25, 50mg/kg) were administered i.p. along with a fixed dose of fluoxetine (15mg/kg) to severe seizure genetically epilepsy-prone rats, the severity of audiogenic seizures...

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