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Hepatitis C Virus core protein (HCVc) plays important roles in the development of intrahepatic cholangiocarcinoma (ICC). MicroRNAs (miRNAs) contribute to tumor progression by interacting with downstream target genes. However, the regulation and role of miRNAs in HCV-related intrahepatic cholangiocarcinoma (HCV-ICC) is poorly understood. In this study, we found that miR-124 was down-regulated in HCV-ICC...
A simple study of the information available within proteins of known structure reveals both the limits of structure prediction based on overall statistical correlations between sequence and structure, and the areas where there is still a possibility for further structural database exploitation.
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