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The rapid differentiation of monocytes into macrophages (MΦ) and dendritic cells is a pivotal aspect of the innate immune response. Differentiation is triggered following recognition of microbial ligands that activate pattern recognition receptors or directly by pro‐inflammatory cytokines. We demonstrate that interleukin‐1β (IL‐1β) induces the rapid differentiation of monocytes into CD209+MΦ, similar...
Intestinal mononuclear phagocytes (iMNP) are critically involved in mucosal immunity and tissue homeostasis. Two major non‐overlapping populations of iMNP have been identified in mice. CD103+ iMNP represent a migratory population capable of inducing tolerogenic responses, whereas CX3CR1+ iMNP are resident cells with disease‐promoting potential. CX3CR1+ iMNP can further be subdivided based on differential...
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