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Transforming growth factor-β1 (TGFβ1) induces plasminogen activator inhibitor-1 (PAI-1) as a major target protein. PAI-1 is associated with fibrosis, thrombosis, and metabolic disorders. TGFβ1 induces PAI-1 via phosphorylation and nuclear translocation of Smads. Oltipraz inhibits TGFβ1 expression and also regenerates cirrhotic liver. Nevertheless, whether oltipraz modulates TGFβ1-mediated cell signaling...
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