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Adrenergic activation has a central role in the development of HF. The function of the β 1 - and the α 2C -adrenergic receptors is influenced by gene polymorphisms: the β 1 Arg389 variant is associated with increased β 1 -receptor sensitivity and the α 2C -receptor Del322-325 variant is associated with decreased α 2C receptor function and increased norepinephrine...
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