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We quantified hepatitis C virus (HCV) RNA at different times in plasma and peripheral blood mononuclear cells (PBMC) in 51 patients with chronic hepatitis C undergoing interferon-α2a (IFN-α2a) therapy. HCV RNA loads in plasma correlated with those in PBMC before and during the treatment (P < 0.001). After treatment, a sustained response was observed in 19 patients (SR), a response followed by relapse...
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