Search results for: Joseph B. Selvanayagam

Items from 1 to 20 out of 74 results

article

Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards

Jing X. Quah, Dhani Dharmaprani, Kathryn Tiver, Anandaroop Lahiri, more

Journal of Cardiovascular Electrophysiology > 32 > 4 > 1147 - 1160

Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical practice. However, current therapeutic interventions for atrial fibrillation have limited clinical efficacy as a consequence of major knowledge gaps in the mechanisms sustaining atrial fibrillation. From a mechanistic perspective, there is increasing evidence that atrial fibrosis plays a central role in the maintenance...

article

The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults

Mitchell C. Lock, Ross L. Tellam, Kimberley J. Botting, Kimberley C. W. Wang, more

The Journal of Physiology > 596 > 23 > 5625 - 5640

Myocardial infarction is a primary contributor towards the global burden of cardiovascular disease. Rather than repairing the existing damage of myocardial infarction, current treatments only address the symptoms of the disease and reducing the risk of a secondary infarction. Cardiac regenerative capacity is dependent on cardiomyocyte proliferation, which concludes soon after birth in humans and precocial...

article

Novel cardiovascular magnetic resonance oxygenation approaches in understanding pathophysiology of cardiac diseases

Karthigesh Sree Raman, Gaetano Nucifora, Joseph B Selvanayagam

Clinical and Experimental Pharmacology and Physiology > 45 > 5 > 475 - 480

Cardiovascular magnetic resonance imaging (CMR) permits accurate phenotyping of many cardiac diseases. CMR’s inherent advantages are its non‐invasive nature, lack of ionizing radiation and high accuracy and reproducibility. Furthermore, it is able to assess many aspects of cardiac anatomy, structure and function. Specifically, it can characterize myocardial tissue, myocardial function, myocardial...

article

Impact of Late Gadolinium Enhancement on mortality, sudden death and major adverse cardiovascular events in ischemic and nonischemic cardiomyopathy: A systematic review and meta-analysis

Anand N. Ganesan, James Gunton, Gaetano Nucifora, Andrew D. McGavigan, more

International Journal of Cardiology > 2018 > 254 > C > 230-237

The central role of left ventricular ejection fraction (LVEF) as the definitive risk marker of adverse outcomes in ischemic and nonischemic cardiomyopathy is increasingly uncertain. The current study aimed to conduct a systematic review and meta-analysis with the objective of evaluating the prognostic importance of Late Gadolinium Enhancement (LGE) in ischemic cardiomyopathy (ICM) and non-ischemic...

article

Predicting Cardiac Prognosis in Asymptomatic Chronic Kidney Disease Patients

Ranjit Shah, Jonathan M. Gleadle, Joseph B. Selvanayagam

JACC: Cardiovascular Imaging > 2018 > 11 > 2(P1) > 286-287

article

The prognostic value of T1 mapping and late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with light chain amyloidosis

Lu Lin, Xiao Li, Jun Feng, Kai-ni Shen, more

Journal of Cardiovascular Magnetic Resonance > 2018 > 20 > 1 > 1-11

Background Cardiac impairment is associated with high morbidity and mortality in immunoglobulin light chain (AL) type amyloidosis, for which early identification and risk stratification is vital. For myocardial tissue characterization, late gadolinium enhancement (LGE) is a classic and most commonly performed cardiovascular magnetic resonance (CMR) parameter. T1 mapping with native T1 and extracellular...

article

Noninvasive imaging in cardiac deposition diseases

Ranjit Shah, Gaetano Nucifora, Rebecca Perry, Joseph B. Selvanayagam

Journal of Magnetic Resonance Imaging > 47 > 1 > 44 - 59

Infiltrative cardiomyopathy represents a heterogeneous group of diseases of the heart tissue with similar phenotypic expression. The condition is rare, but can be easily mistaken for other more common conditions of the heart. The diagnosis of infiltrative cardiomyopathy is therefore challenging and has often required the use of invasive procedures in the past. In the last decade there have been great...

article

Cardiac magnetic resonance evaluation of left ventricular functional, morphological, and structural features in children and adolescents vs. young adults with isolated left ventricular non-compaction

Gaetano Nucifora, Karthigesh Sree Raman, Daniele Muser, Ranjit Shah, more

International Journal of Cardiology > 2017 > 246 > C > 68-73

To investigate the left ventricular (LV) functional, morphological, and structural features revealed by cardiac magnetic resonance (CMR) in children/adolescents with isolated LV non-compaction (iLVNC), and to compare them with those observed in young adults with iLVNC and healthy controls.56 subjects were included: 12 children/adolescents (mean age 15±3years, 75% male) and 20 young adults (mean age...

article

Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging

An Qi Duan, Mitchell C. Lock, Sunthara Rajan Perumal, Jack R. Darby, more

Journal of Cardiovascular Magnetic Resonance > 2017 > 19 > 1 > 1-11

Background Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging has enabled the accurate assessment of myocardial infarction (MI). However, LGE CMR has not been performed successfully in the fetus, where it could be useful for animal studies of interventions to promote cardiac regeneration. We believe that LGE imaging could allow us to document the presence, extent and...

article

Prevalence, Correlates, and Prognostic Relevance of Myocardial Mechanical Dispersion as Assessed by Feature-Tracking Cardiac Magnetic Resonance After a First ST-Segment Elevation Myocardial Infarction

Daniele Muser, Chiara Tioni, Ranjit Shah, Joseph B. Selvanayagam, more

The American Journal of Cardiology > 2017 > 120 > 4 > 527-533

Postinfarction mechanical dispersion (MD), that is, the regional heterogeneity of myocardial contraction throughout the cardiac cycle, has detrimental effects on left ventricular (LV) function and is related to the occurrence of heart failure and ventricular arrhythmias. However, its prevalence, pathophysiological determinants, and clinical utility are still unknown. The aim of the present study is...

article

Cardiovascular magnetic resonance‐GUIDEd management of mild to moderate left ventricular systolic dysfunction (CMR GUIDE): Study protocol for a randomized controlled trial

Joseph B. Selvanayagam, Trent Hartshorne, Laurent Billot, Suchi Grover, more

Annals of Noninvasive Electrocardiology > 22 > 4 > n/a - n/a

Background The majority of sudden cardiac death (SCD) in patients with heart failure occurs in those with mild‐moderate left ventricular (LV) systolic dysfunction (LVEF 36–50%) who under current guidelines are ineligible for primary prevention implantable cardiac defibrillator (ICD) therapy. Recent data suggest that cardiac magnetic resonance (CMR) evidence of replacement fibrosis forms a substrate...

article

Detection of Coronary Stenosis at Rest Using BOLD-CMR

J. Ranjit Arnold, Michael Jerosch-Herold, Theodoros D. Karamitsos, Jane M. Francis, more

JACC: Cardiovascular Imaging > 2017 > 10 > 5 > 600-601

article

Arrhythmogenic right ventricular cardiomyopathy with biventricular involvement and heart failure in a 9-year old girl

Fateh Ali Tipoo Sultan, Mehnaz Atiq Ahmed, Jamie Miller, Joseph B. Selvanayagam

Journal of the Saudi Heart Association > 2017 > 29 > 2 > 139-142

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is seldom recognized clinically in infancy or under the age of 10. We report a case of a 9-year-old girl with ARVC, who presented with signs and symptoms of heart failure and palpitations. Holter monitoring showed frequent premature ventricular beats and echocardiogram revealed dilated and dysfunctional right ventricle with normal tricuspid valve...

article

Changes of left ventricular mechanics after trans-catheter aortic valve implantation and surgical aortic valve replacement for severe aortic stenosis: A tissue-tracking cardiac magnetic resonance study

Gaetano Nucifora, John-Paul Tantiongco, Gareth Crouch, Jayme Bennetts, more

International Journal of Cardiology > 2017 > 228 > C > 184-190

Left ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). The aim of the present study was to assess their changes early and late after trans-catheter aortic valve implantation (TAVI) and surgical aortic valve replacement (AVR) using cardiac magnetic resonance (CMR) tissue-tracking imaging.In 59 patients with severe AS undergoing either TAVI (n=35) or surgical AVR...

article

Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging

Gaetano Nucifora, Carl Gillebert, Joseph B. Selvanayagam

International Journal of Cardiology > 2016 > 223 > C > 881-882

chapter

Infiltrative Cardiomyopathy

Joseph B. Selvanayagam, Majo Joseph, Stefan Neubauer

The ESC Textbook of Cardiovascular Imaging > Cardiomyopathies > 437-448

Infiltrative cardiomyopathy can result from a wide spectrum of both inherited and acquired conditions with varying systemic manifestations. They usually portend an adverse prognosis, although in rare instances (e.g. Fabry’s disease) early diagnosis can result in potentially curative treatment. Cardiac amyloid remains the archetypal infiltrative cardiomyopathy and is discussed in great detail in this...

article

Non-Invasive Cardiac Imaging: Past, Present and Future

Joseph B. Selvanayagam

Heart, Lung and Circulation > 2016 > 25 > 8 > 755-756

article

Cardiac Magnetic Resonance Imaging Before Coronary Artery Bypass Graft Surgery: Is It Ready for Risk Stratification?

Gaetano Nucifora, Joseph B. Selvanayagam

Heart, Lung and Circulation > 2016 > 25 > 6 > 535-537

article

International Mobile-Health Intervention on Physical Activity, Sitting, and Weight

Anand N. Ganesan, Jennie Louise, Matthew Horsfall, Shane A. Bilsborough, more

Journal of the American College of Cardiology > 2016 > 67 > 21 > 2453-2463

Although proof-of-concept for mobile health (mHealth) life-style programs targeting physical inactivity and overweight/obesity has been established in randomized trials, the feasibility and effect of a globally distributed, large-scale, mass-participation mHealth implementation has not been investigated.The purpose of this study was to determine the effect of Stepathlon, an international, low-cost,...

article

Instantaneous Decrease in Left Ventricular Afterload during Transcatheter Aortic Valve Implantation Results in Immediate Changes in Left Ventricular Strain

Amy Swan, Roshan Prakash, Derek P. Chew, Rebecca Perry, more

Echocardiography > 33 > 5 > 742 - 748

Severe aortic stenosis causes chronic increased afterload on the left ventricle (LV) resulting in myocardial hypertrophy and ultimately dysfunction if left untreated. Transcatheter aortic valve implantation (TAVI) immediately decreases the afterload on the LV by reducing the pressure gradient through the aortic valve. In our study, we aim to evaluate immediate changes in LV mechanics using intra‐procedural...

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Search results for: Joseph B. Selvanayagam

Atrial fibrosis and substrate based characterization in atrial fibrillation: Time to move forwards

The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults

Novel cardiovascular magnetic resonance oxygenation approaches in understanding pathophysiology of cardiac diseases

Impact of Late Gadolinium Enhancement on mortality, sudden death and major adverse cardiovascular events in ischemic and nonischemic cardiomyopathy: A systematic review and meta-analysis

Predicting Cardiac Prognosis in Asymptomatic Chronic Kidney Disease Patients

The prognostic value of T1 mapping and late gadolinium enhancement cardiovascular magnetic resonance imaging in patients with light chain amyloidosis

Noninvasive imaging in cardiac deposition diseases

Cardiac magnetic resonance evaluation of left ventricular functional, morphological, and structural features in children and adolescents vs. young adults with isolated left ventricular non-compaction

Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging

Prevalence, Correlates, and Prognostic Relevance of Myocardial Mechanical Dispersion as Assessed by Feature-Tracking Cardiac Magnetic Resonance After a First ST-Segment Elevation Myocardial Infarction

Cardiovascular magnetic resonance‐GUIDEd management of mild to moderate left ventricular systolic dysfunction (CMR GUIDE): Study protocol for a randomized controlled trial

Detection of Coronary Stenosis at Rest Using BOLD-CMR

Arrhythmogenic right ventricular cardiomyopathy with biventricular involvement and heart failure in a 9-year old girl

Changes of left ventricular mechanics after trans-catheter aortic valve implantation and surgical aortic valve replacement for severe aortic stenosis: A tissue-tracking cardiac magnetic resonance study

Value of novel cardiac magnetic resonance indices for the diagnosis of acute myocarditis: Left ventricular mechanics and parametric mapping imaging

Infiltrative Cardiomyopathy

Non-Invasive Cardiac Imaging: Past, Present and Future

Cardiac Magnetic Resonance Imaging Before Coronary Artery Bypass Graft Surgery: Is It Ready for Risk Stratification?

International Mobile-Health Intervention on Physical Activity, Sitting, and Weight

Instantaneous Decrease in Left Ventricular Afterload during Transcatheter Aortic Valve Implantation Results in Immediate Changes in Left Ventricular Strain

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