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Leptin is a peptide hormone secreted by adipose tissue. Studies have shown that leptin crosses the blood–brain barrier (BBB) by a saturable transport system where it acts within the hypothalamus to regulate food intake and energy expenditure. Leptin also acts in the hippocampus where it facilitates the induction of long-term potentiation and enhances NMDA receptor-mediated transmission. This suggests...
Orexin-A is a peptide produced in the lateral hypothalamus/perifornical area, which stimulates feeding. The production of orexin-A is determined by the metabolic state of the animal. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether orexin-A's effects are NO dependent. Here, we...
Ghrelin is a newly discovered gastric peptide, which has orexigenic effects. Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and stimulates growth hormone and gastrointestinal motility. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether ghrelin's effects...
The processing of visual information during learning and memory is considered to be a vital function of the hippocampus. Some researchers believe that the sole purpose of the hippocampus is to process visuo-spatial information, whereas other investigators believe that the hippocampus integrates cues from multiple sources. In the current studies, we tested the effects of vision loss on a hippocampal...
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