Search results for: Larry W. Daniel

Items from 1 to 16 out of 16 results

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Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling

Chananat Klomsiri, LeAnn C. Rogers, Laura Soito, Anita K. McCauley, more

Free Radical Biology and Medicine > 2014 > 71 > Complete > 49-60

Lysophosphatidic acid (LPA) is a growth factor for many cells including prostate and ovarian cancer-derived cell lines. LPA stimulates H ₂ O ₂ production which is required for growth. However, there are significant gaps in our understanding of the spatial and temporal regulation of H ₂ O ₂ -dependent signaling and the way in which signals are transmitted following receptor...

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Endosomal Hydrogen Peroxide Production Leads to Localized Cysteine Sulfenic Acid Formation on Proteins during Lysophosphatidic Acid-Mediated Cell Signaling

Chananat Klomsiri, LeAnn C. Rogers, Laura Soito, Kimberly J. Nelson, more

Free Radical Biology and Medicine > 2013 > 65 > Supplement 2 > S21-S22

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Localized Hydrogen Peroxide-Dependent Cysteine Oxidation Is Required for Lysophosphatidic Acid Signaling in Ovarian and Prostate Cancer Cells

Larry W. Daniel, Chananat Klomsiri, LeAnn C. Rogers, Kimberly J. Nelson, more

Free Radical Biology and Medicine > 2012 > 53 > Supplement 2 > S33

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Localized Hydrogen Peroxide-Dependent Cysteine Oxidation is Required for Lysophosphatidic Acid Signaling in Ovarian and Prostate Cancer Cells

Kimberly J Nelson, LeAnn C Rogers, Chananat Klomsiri, Laura Soito, more

Free Radical Biology and Medicine > 2011 > 51 > Supplement > S137

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Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells

Jerry A. Saunders, LeAnn C. Rogers, Chananat Klomsiri, Leslie B. Poole, more

Free Radical Biology and Medicine > 2010 > 49 > 12 > 2058-2067

Lysophosphatidic acid (LPA) is produced by tumor cells and is present in the ascites fluid of ovarian cancer patients. To determine the role of endogenous LPA in the ovarian cancer cell line SKOV3, we treated cells with the LPA receptor antagonist VPC32183 and found that it inhibited cell growth and induced apoptosis. Exogenous LPA further stimulated ERK and Akt phosphorylation and NF-κB activity...

article

Novel translocation responses of cytosolic phospholipase A2α fluorescent proteins

Rhonda E. Wooten, Mark C. Willingham, Larry W. Daniel, Christina C. Leslie, more

BBA - Molecular Cell Research > 2008 > 1783 > 8 > 1544-1550

Cytosolic phospholipase A ₂ (cPLA ₂ )α responds to the rise in cytosolic Ca ²⁺ ([Ca ²⁺ ] _i ) attending cell stimulation by moving to intracellular membranes, releasing arachidonic acid (AA) from these membranes, and thereby initiating the synthesis of various lipid mediators. Under some conditions, however, cPLA ₂ α translocation occurs without any corresponding...

article

Fluorescent and Affinity-Based Tools To Detect Cysteine Sulfenic Acid Formation in Proteins

Leslie B. Poole, Chananat Klomsiri, Sarah A. Knaggs, Cristina M. Furdui, more

Bioconjugate Chemistry > 2007 > 18 > 6 > 2004 - 2017

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Algebraic dependency models of protein signal transduction networks from time-series data

Edward E. Allen, Jacquelyn S. Fetrow, Larry W. Daniel, Stan J. Thomas, more

Journal of Theoretical Biology > 2006 > 238 > 2 > 317-330

Signal transduction networks are crucial for inter- and intra-cellular signaling. Signals are often transmitted via covalent modification of protein structure, with phosphorylation/dephosphorylation as the primary example. In this paper, we apply a recently described method of computational algebra to the modeling of signaling networks, based on time-course protein modification data. Computational...

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Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate-stimulated MAPK activation, Cox-2 and IL-8 expression

Leslie T. Grab, Mary W. Kearns, Andrew J. Morris, Larry W. Daniel

BBA - Molecular and Cell Biology of Lipids > 2004 > 1636 > 1 > 29-39

Phospholipase D (PLD) is expressed in many tissues and stimulated by growth factors and cytokines. However, the role of PLD in signal transduction is still not well-understood. Human embryonic kidney (HEK-293) cells exhibit low levels of both PLD1 and PLD2 mRNA, however, only PLD1 protein was detected by Western blot. When either isoform of PLD was stably expressed in HEK-293 cells, we observed an...

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Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases

Paul R.S. Baker, John S. Owen, Andrew B. Nixon, Leslie N. Thomas, more

BBA - Molecular Cell Research > 2002 > 1592 > 2 > 175-184

Human neutrophils (PMN) are potentially a major source of platelet-activating factor (PAF) produced during inflammatory responses. The stimulated synthesis of PAF in PMN is carried out by a phospholipid remodeling pathway involving three enzymes: acetyl-CoA:lyso-PAF acetyltransferase (acetyltransferase), type IV phospholipase A ₂ (cPLA ₂ ) and CoA-independent transacylase (CoA-IT)...

article

Foreword

Larry W. Daniel

BBA - Molecular and Cell Biology of Lipids > 1999 > 1439 > 2 > 119-120

article

Phospholipase D, tumor promoters, proliferation and prostaglandins

Larry W. Daniel, Vicki A. Sciorra, Sujoy Ghosh

BBA - Molecular and Cell Biology of Lipids > 1999 > 1439 > 2 > 265-276

Phosphatidylcholine hydrolysis by phospholipase D is a widespread response to cellular stimulation. However, the downstream signaling events subsequent to phosphatidylcholine hydrolysis are just beginning to be determined. Initially it was proposed that diglyceride formation by phospholipase D and phosphatidate phosphohydrolase resulted in long-term stimulation of protein kinase C. However, recent...

article

Quaternary ammonium analogs of ether lipids inhibit the activation of protein kinase C and the growth of human leukemia cell lines

Francesca Civoli, Larry W. Daniel

Cancer Chemotherapy and Pharmacology > 1998 > 42 > 4 > 319-326

AbstractPurpose: ET-18-OCH3 (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) is a representative of the first generation of antitumor ether lipids and is a model in the development of new compounds including a series of quaternary ammonium analogs (QAA). In the present study, we evaluated the QAA as inhibitors of cell growth and studied their mechanism of action. Methods: We compared the effects...

article

Characterization of an HL-60 cell variant resistant to the antineoplastic ether lipid 1-O-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine

George W. Small, Jay C. Strum, Larry W. Daniel

Lipids > 1997 > 32 > 7 > 715-723

A resistant cell line (HL-60R) was selected by incubating HL-60 cells with increasing concentrations of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH₃) and used to examine the mechanism of resistance to the antineoplastic ether-linked lipid. The HL-60R cells exhibited a>10-fold increase in resistance when measured by [³H]-thymidine incorporation in comparison to the HL-60 cell...

article

Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment

Keiichi Fujiwara, Larry W. Daniel, Edward J. Modest, C. Anne Wallen

Cancer Chemotherapy and Pharmacology > 1994 > 34 > 6 > 472-476

Abstract. The mechanisms that govern the activity and the factors that control the anticancer activity of synthetic ether lipids have not been fully elucidated. In this study, three factors were studied in relationship to cell survival after treatment with 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3): (1) exposure dose, (2) drug uptake, and (3) cell density and cell-cycle distribution...

article

Synthesis and Biological Evaluation of Ether-Linked Derivatives of Phosphatidylinositol

Khalid S. Ishaq, Maria Capobianco, Claude Piantadosi, Alessandro Noseda, more

Pharmaceutical Research > 1989 > 6 > 3 > 216-224

The synthesis of two novel glycero-3-phosphoinositol ether lipid analogues, rac-l-O-octadecyl-2-O methylglycero-3-phospho-myo-inositol 6 (an ether lipid analogue of rac-l-O-octadecyl-2-O-methylglycero-3-phosphocholine; ET-18-OMe) and rac-l-O-octadecyl-2-O-acetylglycero-3-phospho-myo-inositol 11 (an ether lipid analogue of platelet-activating factor), is described. The two target compounds and the...

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