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During the past half-century, the cornerstone of treatment for brain metastases has been whole brain irradiation (WBI). WBI has multiple salutary effects including rapid relief of neurological signs and symptoms as well as enhanced local control. Unfortunately, WBI may also engender side effects including memory deficits and decrements in quality of life. Since memory control is thought to be mediated...
Irradiation remains the cornerstone of management for glioblastoma multiforme. The Radiation Therapy Oncology Group and European Organization for Research and Treatment of Cancer advocate encompassing the primary tumor plus a 2-cm margin in the high-dose volume. One shortcoming of this approach is the exposure of critical structures to radiation doses that could exceed organ tolerance. We investigated...
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