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Aims
RPR 102681, a cholecystokinin‐B antagonist, increased dopamine (DA) release and reduced cocaine self‐administration in animals. This pilot study sought to assess the safety and pharmacokinetics (PK) of co‐administration of RPR 102681 and cocaine, and to confirm the DA release mechanism of RPR 102681.
Methods
Sixteen cocaine‐dependent participants were randomized to either placebo or RPR102681...
Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet to substantiate these findings. Using positron emission tomography (PET) scans with high-specific-activity [ 11 C] raclopride and a reference tissue approach, we compared baseline striatal dopamine binding potential...
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