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It is known that a stimulation of vagal afferents induces an inspiratory (I) off-switch. This phenomenon is considered as a neural basis of the Hering-Breuer's ''inflation reflex''. However, the neural correlates underlying the ''deflation reflex'', originally described as a promotion of inspiration under lung deflation, are still unclear. To study this mechanism, we stimulated the vagal afferent...
We have shown previously that the inactivation of the zinc finger gene Krox-20 affects hindbrain segmentation, resulting in the elimination of rhombomeres 3 and 5. We demonstrate here that Krox-20 homozygous mutant mice exhibit abnormally slow respiratory and jaw opening rhythms, indicating that a modification of hindbrain segmentation influences the function of neuronal networks after birth. Central...
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