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CD300a, a membrane protein expressed on myeloid lineages and specific subsets of CD4+ T cells, has been reported to have inhibitory activities in cellular activation. However, the role of CD300a in Toll‐like receptor (TLR) ‐mediated macrophage activation has not been investigated. The human monocytic cell lines THP‐1 and U937 were stimulated with various TLR ligands after triggering of CD300a with...
B‐cell activation factor of the tumour necrosis factor family (BAFF), an important regulator of B‐cell survival, has recently been found to be expressed on the surface of murine and human macrophages and engagement with its receptor was shown to trigger induction of pro‐inflammatory mediators and block phagocytic activity. In an effort to generate immunomodulatory agents that can regulate BAFF‐mediated...
Members of the tumour necrosis factor superfamily play an essential role in inducing various biological responses including proliferation, differentiation, survival and cell death. A proliferation‐inducing ligand (APRIL), first identified as a stimulant of tumour proliferation, is now known as a regulator of B‐cell‐mediated immune responses through the modulation of B‐cell survival and activation...
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