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Positively Charged Liposomes
Systemic delivery of positively charged fusogenic liposomes loaded with a stimulator of interferon genes (STING) agonist (PoSTING) selectively targets the tumor microenvironment and suppresses aberrant tumor angiogenesis. PoSTING can convert non‐inflamed cold tumors (upper) into inflamed hot tumors (lower) by normalizing tumor blood vessels (red) and promoting CD8+ T cell...
Although stimulator of interferon genes (STING) agonists has shown great promise in preclinical studies, the clinical development of STING agonist therapy is challenged by its limited systemic delivery. Here, positively charged fusogenic liposomes loaded with a STING agonist (PoSTING) are designed for systemic delivery and to preferentially target the tumor microenvironment. When PoSTING is administered...
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