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The unsupervised analysis of data-sets, both large in dimension as well as in number of objects, are one of the most challenging tasks in data intense sciences. Especially in astronomy, dedicated survey telescopes generate an enormous amount of complex data. For example the database of the Sloan Digital Sky Survey (SDSS DR10) contains 3 million spectra with ca. 5,000 values each. Analyzing those spectra...
Generally, models of cardiac electrophysiology describe physiologic conditions in detail. However, other conditions, such as drug interactions or mutations of ion channels are of interest for research. Therefore, the simulated ion currents have to be fitted to measured voltage or patch clamp data. In this work, three different methods for the model parametrization were compared: one based on Powell's...
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