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The P2Y 1 and P2Y 12 purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Evidence from P2Y 1 knockout studies as well as from nucleotide-based small molecule P2Y 1 antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders....
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