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Macrophages are important tissue resident cells that regulate the dynamics of inflammation. However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that podoplanin was expressed on a subset of F4/80 + macrophages; a subset which we have termed fibroblastic macrophages...
Lymphoid tissue inducer cells (LTi) play an important role in the development of lymphoid tissue in embryos. Adult CD4+CD3− LTi‐like cells present a similar phenotype and gene expression to their embryonic counterpart and have important roles in CD4+ T‐cell memory and lymphoid tissue recovery following viral infection. However, adult LTi‐like cells are heterogeneous populations and the factors that...
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