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Insulin plays important role in testicular functions such as germ cell proliferation and steroidogenesis, despite its conventional role as a hypoglycaemic agent. It is also well known that testicular activity is severely get affected by heat stress and heat stress induces testicular pathogenesis. The effect of insulin on heat‐induced testicular impairment has not been investigated. Thus, it is hypothesized...
Type 2 diabetes mellitus impairs reproductive functions in men, and important tasks are deciphering the mechanisms of testicular dysfunctions in diabetes and the search of effective approaches to their correction. The purpose was to study the effect of four‐week metformin treatment (120 mg kg−1 day−1) of male Wistar rats with high‐fat diet/low‐dose streptozotocin‐induced type 2 diabetes on basal and...
The functions of mammalian testis are temperature‐sensitive. There are various testicular factors, which express in response to heat as a mechanism of defence. PGC‐1α and HSP70 have poetical role in the protection from oxidative stress in various tissues, including testis. The expression of PGC‐1α and HSP70 has been shown in the testis, and it has also been documented that heat modulates the expression...
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