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The yeast Set1 histone H3 lysine 4 (H3K4) methyltransferase contains, in addition to its catalytic SET domain, a conserved RNA recognition motif (RRM1). We present here the crystal structure and the secondary structure assignment in solution of the Set1 RRM1. Although RRM1 has the expected βαββαβ RRM-fold, it lacks the typical RNA-binding features of these modules. RRM1 is not able to bind RNA by...
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