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1. Skeletal muscle oxidative function and metabolic gene expression are co‐ordinately downregulated in metabolic diseases such as insulin resistance, obesity and Type 2 diabetes. Altering skeletal muscle metabolic gene expression to favour enhanced energy expenditure is considered a potential therapy to combat these diseases.
2. Histone deacetylases (HDACs) are chromatin‐remodelling enzymes that repress...
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