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Self‐Oxygenating Tissues
In article number 2100850, Jeroen Leijten and co‐workers produce oxygen‐generating micromaterials composed of polycaprolactone and calcium peroxide to engineer self‐oxygenating living implants. Upon implantation, the self‐oxygenation of tissues improve cell survival, enhance production of angiogenic factors, and orchestrate full‐thickness vascularization. Self‐oxygenation...
Bioengineering of tissues and organs has the potential to generate functional replacement organs. However, achieving the full‐thickness vascularization that is required for long‐term survival of living implants has remained a grand challenge, especially for clinically sized implants. During the pre‐vascular phase, implanted engineered tissues are forced to metabolically rely on the diffusion of nutrients...
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