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Rationale Some recent pharmacoepidemiological studies revealed an elevated risk of driving accidents after opioid analgesics uses. Among analgesics, codeine is often associated with paracetamol in numerous pharmaceutical specialties. Objectives The objective of this study was to evaluate the dose–effect relationship of three usual therapeutic doses of codeine/paracetamol on driving ability, psychomotor...
Rationale Although hypnotics are primarily used by older people, the residual effects the morning after a single nighttime intake of the two most commonly prescribed hypnotics, zolpidem (Zp) and zopiclone (Zc), on older middle-aged drivers have not been evaluated and compared. Methods Sixteen healthy subjects, 55 to 65 years of age, participated in this double-blind, balanced, cross-over study....
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