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To investigate the hepatoprotective effect of total saponin from Ornithogalum saundersiae Ait (Liliaceae) (OC) against acetaminophen (APAP)-induced acute liver injury in vivo and in vitro. Mice were pretreated with OC (300, 200 or 100 mg·kg −1 , body weight) or N-acetyl-L-cysteine (NAC) (300 mg·kg −1 , body weight) for 3 times at 24 h intervals. APAP was administered 2 h after OC...
The protective effect of a diterpenoid acanthoic acid (AA) isolated from Acanthopanax koreanum Nakai was investigated in acetaminophen (APAP)-induced hepatic toxicity. Drug-induced hepatotoxicity induced by an intraperitoneal (i.p.) injection of 300mg/kg (sub-lethal dose) of APAP. Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase...
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