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dl-Lactic acid was grafted onto chitosan to produce poly(chitosan-g-dl-lactic acid)(PCLA) copolymers. These PCLAs were then spun into submicron and/or nanofibers to fabricate scaffolds using an electro-wet-spinning technique. The diameter of fibers in different scaffolds could vary from about 100nm to around 3μm. The scaffolds exhibited various pore sizes ranging from about 1μm to less than 30μm and...
Porous poly(dl-lactide)(PDLLA)/chitosan scaffolds with well-controlled pore structures and desirable mechanical characteristics were fabricated via a combination of solvent extraction, phase separation and freeze-drying. These scaffolds were further evaluated for the proliferation of isolated rabbit chondrocytes in vitro for various incubation periods up to 4 weeks in order to finally use them for...
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