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Active-targeting nanocarriers can significantly improve the transcytosis of poorly water-soluble or bio-macromolecular drugs across biological barrier. However, reasons for the improvement are not understood enough, which hampered the reasonable design of active targeting nanocarriers. To illustrate how different factors influence the transport of active-targeting nanocarriers, we established ligand-decorated...
Since they were first reported in 1980, site-specific drug delivery nanocarriers have progressed greatly with the development of nanotechnology and biotechnology, especially in the anti-tumor field. Currently, some of the ligand peptides like RGD have become hot targeting molecules with extensive academic studies and some receptor-medicated nanocarriers are now in clinical trials. Homing peptides...
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