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2D-gel electrophoresis (2DGE) is an important technique in proteomics for analyzing the protein expressions. However, the analysis of 2DGE images is still a cumbersome and tedious task. One of the main reasons is the presence of a large amount of the inhomogeneities in the foreground and the background intensities. In this paper, we have proposed a novel approach of segmentation of the protein spots...
A bio-chip arrayer system has been developed indigenously for producing bio-chips. The bio-chips are based on use of track etched membranes (TEM) as a novel solid support. TEM are extremely thin (10 micron) and highly microporous membranes. We have tested polycarbonate (PC) TEM by manual spotting of antibodies for the development of the antibody bio-chip for simultaneous estimation of the thyroid...
Proteomics is a well established subject in medical science, which focuses on the library of proteins specific to a given bio-system, the proteome, and understanding of relationships therein. It is a very challenging task to find out the correct position coordinates of all the proteins in the 2D gel, because proteins change their position in each experiment according to their mass and charge with...
Segmentation of two dimensional electrophoresis (2DE) gel image is a challenging task due to presence of nonlinear backgrounds, horizontal and vertical streaks, and irregular spots. The watershed method is a powerful tool for medical image segmentation, but it produces over-segmented results due to presence of noise and non-linearity. The solutions available in literature have failed to give satisfactory...
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