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Regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or nonself-antigens, thus playing critical roles in the prevention of autoimmune diseases, but they may inhibit antitumor immunity and promote tumor growth. Increasing evidence demonstrates that elevated proportions of CD4 + Treg cells are present in various types of cancers and suppress antitumor...
Regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non-self-antigens, thus playing critical roles in preventing autoimmune diseases. However, tumor cells may take advantage of Treg cells to protect themselves from immune attack elicited by vaccines. Recent studies demonstrate the presence of Treg cells in various types of cancers and their suppressive...
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