Search results for: Elise F. Morgan

Items from 1 to 20 out of 42 results

article

Geometric determinants of the mechanical behavior of image‐based finite element models of the intervertebral disc

Ingmar Fleps, Harrah R. Newman, Dawn M. Elliott, Elise F. Morgan

Journal of Orthopaedic Research® > 42 > 6 > 1343 - 1355

The intervertebral disc is an important structure for load transfer through the spine. Its injury and degeneration have been linked to pain and spinal fractures. Disc injury and spine fractures are associated with high stresses; however, these stresses cannot be measured, necessitating the use of finite element (FE) models. These models should include the disc's complex structure, as changes in disc...

article

Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci

Abdullah Abood, Larry Mesner, Will Rosenow, Basel M. Al‐Barghouthi, more

Journal of Bone and Mineral Research > 37 > 8 > 1500 - 1510

Osteoporosis, characterized by low bone mineral density (BMD), is the most common complex disease affecting bone and constitutes a major societal health problem. Genome‐wide association studies (GWASs) have identified over 1100 associations influencing BMD. It has been shown that perturbations to long noncoding RNAs (lncRNAs) influence BMD and the activities of bone cells; however, the extent to which...

article

Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine Is Associated With Prevalent Vertebral Fracture

Jarred Kaiser, Brett Allaire, Paul M Fein, Darlene Lu, more

Journal of Bone and Mineral Research > 35 > 4 > 641 - 648

The spatial heterogeneity in trabecular bone density within the vertebral centrum is associated with vertebral strength and could explain why volumetric bone mineral density (vBMD) exhibits low sensitivity in identifying fracture risk. This study evaluated whether the heterogeneity and spatial distribution of trabecular vBMD are associated with prevalent vertebral fracture. We examined the volumetric...

article

Correspondence between bone mineral density and intervertebral disc degeneration across age and sex

Jarred Kaiser, Brett Allaire, Paul M. Fein, Darlene Lu, more

Archives of Osteoporosis > 2018 > 13 > 1 > 1-9

SummaryThe distribution of bone tissue within the vertebra can modulate vertebral strength independently of average density and may change with age and disc degeneration. Our results show that the age-associated decrease in bone density is spatially non-uniform and associated with disc health, suggesting a mechanistic interplay between disc and vertebra. Purpose While the decline of bone mineral...

article

Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice

James Watt, Amelia H. Baker, Brett Meeks, Paola D. Pajevic, more

Journal of Cellular Physiology > 233 > 9 > 7007 - 7021

The retinoid X receptors (RXR), peroxisome proliferator activated receptor gamma (PPARγ), and liver X receptors (LXR) all have been shown to regulate bone homeostasis. Tributyltin (TBT) is an environmental contaminant that is a dual RXRα/β and PPARγ agonist. TBT induces RXR, PPARγ, and LXR‐mediated gene transcription and suppresses osteoblast differentiation in vitro. Bone marrow multipotent mesenchymal...

article

Correlation between RUST assessments of fracture healing to structural and biomechanical properties

Margaret E. Cooke, Amira I. Hussein, Kyle E. Lybrand, Alexander Wulff, more

Journal of Orthopaedic Research® > 36 > 3 > 945 - 953

Radiographic Union Score for Tibia (RUST) and modified RUST (mRUST) are radiographic tools for quantitatively evaluating fracture healing using a cortical scoring system. This tool has high intra‐class correlation coefficients (ICCs); however, little evidence has evaluated the scores against the physical properties of bone healing. Closed, stabilized fractures were made in the femora of C3H/HeJ male...

article

Erratum: “BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing” [J Orthop Res. Vol 34, 2096–2105 (2016)]

Elise F. Morgan, Jason Pittman, Anthony DeGiacomo, Daniel Cusher, more

Journal of Orthopaedic Research® > 36 > 3 > 1040 - 1040

article

Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?

Paul M. Fein, Alexander DelMonaco, Timothy M. Jackman, Cameron Curtiss, more

Journal of Biomechanics > 2017 > 64 > C > 41-48

The coupling of the intervertebral disc (IVD) and vertebra as a biomechanical unit suggests that changes in the distribution of pressure within the IVD (intradiscal pressure, IDP) as a result of disc degeneration can influence the distribution of bone density within the vertebra, and vice versa. The goal of this study was to assess the correspondence between IDP and bone density in the adjacent vertebrae,...

article

Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice

Beth Bragdon, Stephanie Lam, Sherif Aly, Alexandra Femia, more

Bone > 2017 > 101 > C > 49-61

Endochondral ossification is the process where cartilage forms prior to ossification and in which new bone forms during both fracture healing and ectopic bone formation. Transitioning to ossification is a highly coordinated process between hypertrophic chondrocytes, vascular endothelial cells, osteoblasts and osteoclasts. A critical biological process that is central to the interactions of these various...

article

BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing

Elise F. Morgan, Jason Pittman, Anthony DeGiacomo, Daniel Cusher, more

Journal of Orthopaedic Research® > 34 > 12 > 2096 - 2105

A soluble form of BMP receptor type 1A (mBMPR1A‐mFC) acts as an antagonist to endogenous BMPR1A and has been shown to increase bone mass in mice. The goal of this study was to examine the effects of mBMPR1A‐mFC on secondary fracture healing. Treatment consisted of 10 mg/kg intraperitoneal injections of mBMPR1A‐mFC twice weekly in male C57BL/6 mice. Treatment beginning at 1, 14, and 21 days post‐fracture...

article

Bone mechanical properties and changes with osteoporosis

Georg Osterhoff, Elise F. Morgan, Sandra J. Shefelbine, Lamya Karim, more

Injury > 2016 > 47 > S2 > S11-S20

This review will define the role of collagen and within-bone heterogeneity and elaborate the importance of trabecular and cortical architecture with regard to their effect on the mechanical strength of bone. For each of these factors, the changes seen with osteoporosis and ageing will be described and how they can compromise strength and eventually lead to bone fragility.

article

Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion

Timothy M Jackman, Amira I Hussein, Cameron Curtiss, Paul M Fein, more

Journal of Bone and Mineral Research > 31 > 4 > 777 - 788

The biomechanical mechanisms leading to vertebral fractures are not well understood. Clinical and laboratory evidence suggests that the vertebral endplate plays a key role in failure of the vertebra as a whole, but how this role differs for different types of vertebral loading is not known. Mechanical testing of human thoracic spine segments, in conjunction with time‐lapsed micro–computed tomography,...

article

Accuracy of finite element analyses of CT scans in predictions of vertebral failure patterns under axial compression and anterior flexion

Timothy M. Jackman, Alex M. DelMonaco, Elise F. Morgan

Journal of Biomechanics > 2016 > 49 > 2 > 267-275

Finite element (FE) models built from quantitative computed tomography (QCT) scans can provide patient-specific estimates of bone strength and fracture risk in the spine. While prior studies demonstrate accurate QCT-based FE predictions of vertebral stiffness and strength, the accuracy of the predicted failure patterns, i.e., the locations where failure occurs within the vertebra and the way in which...

article

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice

Loai Alsofi, Eileen Daley, Ian Hornstra, Elise F. Morgan, more

Calcified Tissue International > 2016 > 98 > 2 > 172-185

Lysyl oxidases are required for collagen and elastin cross-linking and extracellular matrix maturation including in bone. The lysyl oxidase family consists of lysyl oxidase (LOX) and 4 isoforms (LOXL1-4). Here we investigate whether deletion of LOXL1, which has been linked primarily to elastin maturation, leads to skeletal abnormalities. Left femurs (n = 8), L5 vertebrae (n = 8), and tibiae (n = 8)...

article

Peripheral Blood‐Derived Endothelial Progenitor Cells Enhance Vertical Bone Formation

Hadar Zigdon‐Giladi, Tova Bick, Elise F. Morgan, Dina Lewinson, more

Clinical Implant Dentistry and Related Research > 17 > 1 > 83 - 92

BackgroundThis study presents a novel cell‐based approach for extra‐cortical bone regeneration. ObjectiveTo enhance vertical bone formation by combining guided bone regeneration and transplantation of peripheral blood‐derived endothelial progenitor cells (EPCs) in a rat calvaria model. Materials and MethodsEPCs were isolated from peripheral blood of inbred rats. Gold domes (7 mm radius, 5 mm height)...

article

Toward Clinical Application and Molecular Understanding of the Mechanobiology of Bone Healing

Elise F. Morgan, Jenny Lei

Clinical Reviews in Bone and Mineral Metabolism > 2015 > 13 > 4 > 256-265

Bone healing is sensitive to mechanical loading. Study of the mechanisms by which mechanical loads modulate healing can yield new strategies for the treatment of bone injuries. This article reviews the basic biological and biomechanical stages of bone healing and then summarizes the phenomenological evidence of the mechanosensitivity of the healing process. We then turn our focus to more mechanistic...

article

Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing

Gregory J. Miller, Louis C. Gerstenfeld, Elise F. Morgan

Biomechanics and Modeling in Mechanobiology > 2015 > 14 > 6 > 1239-1253

Uncovering the mechanisms of the sensitivity of bone healing to mechanical factors is critical for understanding the basic biology and mechanobiology of the skeleton, as well as for enhancing clinical treatment of bone injuries. This study refined an experimental method of measuring the strain microenvironment at the site of a bone injury during bone healing. This method used a rat model in which...

article

Intrinsic Sex‐Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells

Beth Bragdon, Robert Burns, Amelia H. Baker, Anna C. Belkina, more

Journal of Cellular Physiology > 230 > 2 > 296 - 307

Bone formation and aging are sexually dimorphic. Yet, definition of the intrinsic molecular differences between male and female multipotent mesenchymal stromal cells (MSCs) in bone is lacking. This study assessed sex‐linked differences in MSC differentiation in 3‐, 6‐, and 9‐month‐old C57BL/6J mice. Analysis of tibiae showed that female mice had lower bone volume fraction and higher adipocyte content...

article

Endplate deflection is a defining feature of vertebral fracture and is associated with properties of the underlying trabecular bone

Timothy M. Jackman, Amira I. Hussein, Alexander M. Adams, Kamil K. Makhnejia, more

Journal of Orthopaedic Research® > 32 > 7 > 880 - 886

Endplate deflection frequently occurs with vertebral failure, but the relationship between the two remains poorly defined. This study examined associations between endplate deflection under compressive loading and characteristics of the neighboring subchondral bone and intervertebral disc (IVD). Ten L1 vertebrae with adjacent IVDs were dissected, compressed axially in a stepwise manner to failure,...

article

The Effect of the Achilles Tendon on Trabecular Structure in the Primate Calcaneus

Sharon Kuo, Jeremy M. Desilva, Maureen J. Devlin, Gabriel Mcdonald, more

The Anatomical Record > 296 > 10 > 1509 - 1517

Humans possess the longest Achilles tendon relative to total muscle length of any primate, an anatomy that is beneficial for bipedal locomotion. Reconstructing the evolutionary history of the Achilles tendon has been challenging, in part because soft tissue does not fossilize. The only skeletal evidence for Achilles tendon anatomy in extinct taxa is the insertion site on the calcaneal tuber, which...

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INFONA - science communication portal

Search results for: Elise F. Morgan

Geometric determinants of the mechanical behavior of image‐based finite element models of the intervertebral disc

Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci

Heterogeneity and Spatial Distribution of Intravertebral Trabecular Bone Mineral Density in the Lumbar Spine Is Associated With Prevalent Vertebral Fracture

Correspondence between bone mineral density and intervertebral disc degeneration across age and sex

Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice

Correlation between RUST assessments of fracture healing to structural and biomechanical properties

Erratum: “BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing” [J Orthop Res. Vol 34, 2096–2105 (2016)]

Is bone density associated with intervertebral disc pressure in healthy and degenerated discs?

Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice

BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing

Bone mechanical properties and changes with osteoporosis

Quantitative, 3D Visualization of the Initiation and Progression of Vertebral Fractures Under Compression and Anterior Flexion

Accuracy of finite element analyses of CT scans in predictions of vertebral failure patterns under axial compression and anterior flexion

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice

Peripheral Blood‐Derived Endothelial Progenitor Cells Enhance Vertical Bone Formation

Toward Clinical Application and Molecular Understanding of the Mechanobiology of Bone Healing

Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing

Intrinsic Sex‐Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells

Endplate deflection is a defining feature of vertebral fracture and is associated with properties of the underlying trabecular bone

The Effect of the Achilles Tendon on Trabecular Structure in the Primate Calcaneus

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