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Aim
This study investigates for the first time the effect of Porphyromonas gingivalis lipopolysaccharides (Pg‐LPS) on proliferative/regenerative aptitudes of gingival stem/progenitor cells (G‐MSCs).
Material and Methods
G‐MSCs (n = 5) were treated by 0, 10 ng/ml, 100 ng/ml, 1 μg/ml or 10 μg/ml Pg‐LPS. At 1 hour, Toll‐like receptor 4 (TLR‐4) expression and NF‐κB and Wnt/β‐catenin signalling pathways...
Background Protease-activated receptors (PARs) are G-protein-coupled receptors with an active role in mediating inflammation, pain and other functions. The oral pathogen Porphyromonas gingivalis (P. gingivalis) secretes proteases that activate PARs. The aim of this study was to elucidate the role of PARs in the pathogenesis of chronic periodontitis by expression analysis of PARs in human gingival...
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