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We present a straightforward and robust method for simultaneous quantification of succinylacetone and nitisinone in plasma using LC-ESI–MS/MS. The method has been developed for routine therapeutic drug monitoring in hepatorenal tyrosinemia type 1 (HT1) patients undergoing nitisinone treatment. Previous methods are based on separate analyses of succinylacetone and nitisinone, often using the potentially...
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