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Interleukin (IL)‐33, a member in the IL‐1 family, plays a central role in innate and adaptive immunity; however, how IL‐33 mediates cytotoxic T‐cell regulation and the downstream signals remain elusive. In this study, we found increased mouse IL‐33 expression in CD8+ T cells following cell activation via anti‐CD3/CD28 stimulation in vitro or lymphocytic choriomeningitis virus (LCMV) infection in vivo...
Recent studies have revealed IL‐33 as a key factor in promoting antiviral T‐cell responses. However, it is less clear as to how IL‐33 regulates innate immunity. In this study, we infected wild‐type (WT) and IL‐33−/− mice with lymphocytic choriomeningitis virus and demonstrated an essential role of infection‐induced IL‐33 expression for robust innate IFN‐γ production in the liver. We first show that...
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