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Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the `double-drug' approach. The IC 50 values for PLMII inhibition ranged from 0.59 to 400nM and the best IC 50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4μM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
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