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ObjectivesTo gain further evidence on the efficacy, safety and tolerability of tadalafil 5 mg once‐daily in Asian men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
MethodsJapanese and Korean men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia were randomized to once‐daily tadalafil 5 mg (n = 306) or placebo (n = 304) for 12 weeks.
ResultsA...
Study Type – Therapy (RCT)Level of Evidence 1bWhat’s known on the subject? and What does the study add? Phosphodiesterase type 5 inhibitors (PDE 5Is) improve erectile function and lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH), however the exact effects on prostate tissue and its underlying mechanisms remain unclear.PDE 5Is enhanced the production of cyclic nucleotides...
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