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We recently reported that inducible nitric oxide synthase was expressed in advanced atheromatous aortas of cholesterol fed rabbits. So we investigated the effect of nitric oxide (NO) or peroxinitrite induced by inducible nitric oxide synthase (iNOS) to inflammatory cells in atheroma of human colonary artery by immunohistochemistry. iNOS was not detected in normal aortas, initimal thickenings, and...
We evaluated the effect of 17 β-estradiol on atherosclerosis and endothelial function of rabbit aorta induced by high cholesterol diet plus balloon injury. Abdominal aortas of 48 female rabbits were injured by balloon catheter on the 30th day after oophorectomy. They were divided into four groups (GpI: standard diet, GPII: standard diet plus 100 μg/kg/day 17 β-estradiol, GpIII: atherogenic diet...
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