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Abstract: We investigated the involvement of MAPK pathways in the melanogenic effect of apigenin in B16 cells. Apigenin treatment for 48 h dose (5–20 μm)‐dependently up‐regulated protein expression levels of microphthalmia‐associated transcription factor (MITF) and melanogenic enzymes including tyrosinase, tyrosinase‐related protein‐1 (TRP‐1) and TRP‐2 and enhanced the phosphorylation of p38 MAPK,...
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