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Soliton self-frequency shift (SSFS) is a highly versatile technology for generating femotosecond pulses with broadband wavelength tunability. Here we review our recent progress in utilizing SSFS for various modalities of multiphoton microscopy, including both fluorescence microscopy and harmonic generation microscopy.
Optical imaging plays a major role in both basic biological research and clinical diagnostics, providing noninvasive or minimally invasive microscopic imaging capability to investigate biological tissues. Optical image acquisition through significant depths of biological tissues, however, presents a major challenge since tissue is extremely heterogeneous and the strong scattering of the various tissue...
Concatenation of two different higher-order-mode fibers (HOMFs) was used to extend the soliton wavelength shift beyond the mode-crossing wavelengths of the fibers. A 3.5 nJ, 55 fs soliton was obtained at 1170 nm.
We demonstrate 1600–1820 nm tunable MW soliton generation using a solid-core photonic crystal rod pumped by a compact fiber source, and its application to in vivo deep penetration three-photon microscopy in mouse brain.
We report on the mode-locked rectangular pulse operating in dissipative soliton resonance (DSR) region in an anomalous-dispersion figure-eight fiber laser. The results demonstrate that the formation of DSR pulse is independent of mode-locking techniques.
We demonstrate non-invasive, high-resolution, in vivo imaging of subcortical structures (the external capsule (EC) and hippocampus) within an intact mouse brain using three-photon fluorescence microscopy at the new spectral window of 1700 nm.
We demonstrate 67-nJ, 65-fs soliton pulse generation using a solid-core photonic crystal rod pumped by a compact fiber source, and its application to in vivo three-photon microscopy in mouse brain.
We describe the optimization process of a higher order mode fiber capable of producing a soliton with a duration of 119 fs and a pulse energy of 6.3 nJ shifted in wavelength to 1085 nm.
We demonstrate high-energy soliton pulse generation from a large mode area fiber, tunable from 1560 nm up to 1700 nm, pumped with a 10 MHz, 1.5-ps time lens source at 1544 nm.
We demonstrate Cerenkov radiation generation in a higher-order-mode fiber with anomalous dispersion from approximately 700 to 800 nm. Cerenkov radiation at 850 nm with 0.6 nJ pulse energy is generated with 60% power conversion efficiency.
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