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The aim of this study was to determine the toxicokinetics and some effects of 1,1,1-trifluoroethane (HFC-143a) in humans. Nine male volunteers were experimentally exposed to 500ppm HFC-143a for 2h during light physical exercise (50W) in an exposure chamber. Blood, urine and exhaled air were sampled before, during and up to 19h after exposure and analysed for HFC-143a by gas chromatography. These data...
The aim of this study was to determine the uptake and disposition of inhaled 1,1,1,2-tetrafluoroethane (HFC-134a) in humans. Ten male volunteers were exposed to 500ppm HFC-134a (2h, 50W exercise). The HFC-134a levels were monitored in blood, exhaled air and urine up to 19h post-exposure.The concentration in blood increased rapidly, reaching a plateau of 9.4±1.9μM (mean±S.D.) within 30min, followed...
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