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Nitrogen dioxide (NO 2 ) is a ubiquitous reactive free-radical gas, which has been associated with momentary and chronic health effects. In the present study, comet, micronucleus (MN) and DNA–protein crosslinks (DPC) assays were used to investigate the genotoxicity following in vivo inhalation exposure of rats to NO 2 . The results show that inhalation exposure of rats to NO 2...
Epidemiological studies suggest that NO 2 inhalation is associated with adverse effects on heart-related health, however, existing experimental data lack relevant evidences. In this study, a role for oxidative stress, endothelial dysfunction and inflammatory responses in the heart of rats treated with different concentrations of NO 2 (0, 5, 10 and 20mgm −3 ) was investigated...
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