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Sphingolipid deregulation may be an important factor of age-related neuronal stress vulnerability. Current data suggests potential links between sphingosine kinases (SphK1&2), their product sphingosine1-phosphate (S1P) and age-related protein conformation diseases. The aim of this study was to investigate a possible role of SphKs in alpha-synuclein (ASN) and amyloid beta (ABeta) precursor protein...
Neuronal activity greatly infl uences the formation and stabilization of synapses. Although receptors for sphingosine-1-phosphate (S1P), a lipid mediator regulating diverse cellular processes, are abundant in CNS, neuron-specifi c functions of S1P remain largely undefi ned. Here we present novel actions of S1P using primary hippocampal neurons as a model system, i.e. S1P triggers neurotransmitter...
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