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Phosphatidylinositol 3-kinase (PI3-K) has been shown to mediate insulin and insulin-like growth factor-1 (IGF-1)[ndash ]induced nitric oxide (NO) generation and, thus, vascular tone. A role for PI3-K in G-protein[ndash ]coupled receptor signal transduction has also been reported. As [beta ]2 -adrenergic vascular actions are partly dependent on NO, this study the role of PI3-K on in vitro isoproterenol...
We sought to determine whether insulin/insulin-like growth factor-1 (IGF-1) and an insulin-sensitizing agent, troglitazone, have additive vasodilatory effects and the possible involvement of intracellular Ca 2+ ([Ca 2+ ] i ) and/or glucose utilization in these effects. Contractile responses to norepinephrine (NE) and potassium chloride (KCl), as well as relaxation...
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