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Intimal thickening is a stepwise phenomenon under the control of smooth muscle cell differentiation, smooth muscle cells change their integration into the connective tissu and migrate toward the intimal space. In order to evaluate smooth muscle cells differentiation we have done a kinetic of endothelial injury on 20 rabbits under normal diet. Since the maximum of hyperplasia is obtained after 15...
Since mononuclear cells are recruited in atherosclerotic lesions, the expression of adhesion proteins by the arterial endothelium may play a major role in atherogenesis. The relationships between ICAM-1, E-selectin, and VCAM-1 expression on the arterial endothelium and the presence and degree of maturation of intimal macrophages in human atherosclerotic lesions was investigated. By quantitative...
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