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This work concerns a problem of decision in the field of epidemiologica! control. The main objective is the optimal allocation of a limited amount of resources in such a way that the direct and social costs are minimized in terms of co-infection: acquired immune deficiency syndrome (AIDS) and tuberculosis. A mathematical model for the dynamics of the co-infection found in the literature is used together...
BackgroundTAK‐438 (vonoprazan) is a potassium‐competitive acid blocker that reversibly inhibits gastric H+, K+‐ATPase.
AimTo evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TAK‐438 in healthy Japanese and non‐Japanese men.
MethodsIn two Phase I, randomised, double‐blind, placebo‐controlled studies, healthy men (Japan N = 60; UK N = 48) received TAK‐438 10–40 mg once daily...
The A2 harmonization team, a part of the Global Bioanalysis Consortium (GBC), focused on defining possible tiers of chromatographic-based bioanalytical method performance. The need for developing bioanalytical methods suitable for the intended use is not a new proposal and is already referenced in regulatory guidance language. However, the practical implementation of approaches that differ from the...
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