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Acute hypoxia increases ventilatory drive in conscious animals, resulting in tachycardia. Sustained hypoxia changes the initial chemoreflex ventilatory increase to secondary ventilatory depression, which then evokes a gradual secondary heart rate (HR) reduction. Prostacyclin (PGI2) release is known to potentiate α2-adrenoreceptor (α2-AR) mediated inhibition of sympathoactivation during ischaemia and...
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