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Rationale Monoamine releasers with prominent dopaminergic actions, e.g., d-methamphetamine (d-MA), significantly reduce cocaine use and craving in clinical and preclinical laboratory studies. However, D-MA and related drugs also display high abuse potential, which limits their acceptability as agonist replacement medications for the management of Cocaine Use Disorder. Objectives The l-isomer of...
Rationale Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. Objectives The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. Methods In experiment 1, rats self-administered food pellets or injections of 0.19 mg/kg cocaine...
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